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This paper presents a manufacturing process for biological chitosan and chitosan-alginate dressing sponges as well as their biological and physical-mechanical properties. The aim of the research was the preparation of such sponges based on chitosan and chitosanalginate fibrids prepared according to a method elaborated at Institute of Biopolymers and Chemical Fibres (IBWCh). The sponges ought to display physical (absorption ability) and biological features (cytotoxic and haemostatic properties) which would qualify the materials obtained for the healing of wounds throughout all healing phases. Key words: chitosan, calcium alginate, microfibrids, freeze-drying, dressing sponges.
For several years demand has been increasing for biological dressings capable of protecting the wound throughout the various healing phases . Demands placed on dressings designed for healing during the granulation and epithelisation phase are, to a large extent, met by biomaterials that contain healing- stimulating polymers. Polysaccharides, chitosan and alginates in particular are, thanks to specific biological properties like haemostatic, granulation and epithelisation, ideal materials for the construction of dressings suitable for wounds during the various healing phases .
In the preparation of a bioactive dressing material, it is essential to select a proper bioactive polymer and a useful form for it.
Chitosan and chitosan-alginate microand nanofibrids are suitable for the construction of dressings in sponge or nonwoven form.
Commercial dressings based on chitin, chitosan and alginates are offered in large assortment. So far, there have been no announcements in technical literature concerning fibrids used for the preparation of dressing sponges.
Kaltostat® (ConvaTec), Melgisorb® (Molnlycke), SeaSorb® (Coloplast) and Sorbsan® (UDL Laboratories, INC) are examples of alginate dressings which are offered as non-woven plates for surface wounds and ropes for deep wounds . Calcium ions delivered from the alginates to the wound activate the platelets and accelerate homeostasis due the dressings having good exudate absorbency and haemostatic properties. Such materials are designed primarily for wound healing in the first phase.